In the first half of this presentation, Dr. Bernard walks through each common 4H Leukodystrophy symptom and the corresponding management and supportive care available. Although each patient has unique needs, this breakdown helps identify which specialists are generally important to see regularly. Halfway through, Dr. Wolf takes over to explain how future clinical trials should be designed and what we can learn from existing treatment approaches for other leukodystrophies. She illustrates the challenges of finding tailored treatments to address the different forms and stages of 4H Leukodystrophy.